You have a beautiful new Mac with a built-in Infrared port and an Apple Remote control? Front Row is not enough for your needs?
Then try out iRed Lite which pushes IR control to its limits!
Remote control any application by remote keystrokes
Call AppleScripts for finer control
Use your Apple Remote for iTunes, then for iPhoto, then ...
Use multiple Apple Remotes, one for Keynote, another one for VLC, ...
Teach your programmable RC to simulate multiple Apple Remotes
